Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.30 |
| ▸ | KDM4A | O75164 | 1/20 | 0.30 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.30 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL9844145 | 0.91 | OPRD1 (0.37) | ALDH1A1LMNAKDM4EMAPTALOX15 | |
| SCHEMBL122497 | 0.89 | TRPV1 (0.35) | ALDH1A1LMNAMAPTHTTSMN1; SMN2 | |
| Acetic Acid SCHEMBL9844165 | 0.88 | TRPV1 (0.33) | ALDH1A1LMNAMAPTHTTPLA2G10 | |
| Lactic Acid SCHEMBL6445485 | 0.86 | FAAH (0.36) | ALDH1A1LMNAMAPTHTTPLA2G10 | |
| Phosphoric Acid SCHEMBL9844199 | 0.85 | ALDH1A1 (0.33) | ALDH1A1LMNAMAPTTSHRHTT | |
| SCHEMBL123770 | 0.79 | TRPV1 (0.46) | ALDH1A1LMNAHTTSMN1; SMN2 | |
| Acetic Acid SCHEMBL9844375 | 0.78 | TRPV1 (0.43) | ALDH1A1LMNAMAPTHTTSMN1; SMN2 | |
| Phosphoric Acid SCHEMBL9844239 | 0.75 | TRPV1 (0.42) | ALDH1A1LMNAHTTSMN1; SMN2 | |
| Citric Acid SCHEMBL29265484 | 0.69 | HSPD1 (0.55) | ALDH1A1MAPT | |
| Citric Acid SCHEMBL29657509 | 0.69 | ALDH1A1 (0.52) | ALDH1A1LMNAALOX15TSHRKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0410659-A2 | Method and composition to impart improved conditioning properties to the hair | HELENE CURTIS, INC. (US) | 1991-01-30 | — | — | EP | claimed |
| US-4976956-A | Water soluble and oil soluble quaternary ammonium compounds and amidoamine | HELENE CURTIS, INC. (US) | 1990-12-11 | — | — | US | claimed |