SCHEMBL9844478

SCHEMBL9844478

O=C1OC(CCN2CCCC(Cc3ccccc3)C2)CN1c1ccccc1

nearest known ligand 0.60

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
GRM2 Q14416 13/20 0.60
CARM1 Q86X55 2/20 0.52
PRMT6 Q96LA8 2/20 0.52
BCHE P06276 1/20 0.46
SLC6A2 P23975 1/20 0.43
SLC6A4 P31645 1/20 0.43
HTR7 P34969 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9844281 0.93 GRM2 (0.52) GRM2CARM1PRMT6BCHE
SCHEMBL9844088 0.93 GRM2 (0.52) GRM2CARM1PRMT6BCHESLC6A2
SCHEMBL9844290 0.90 GRM2 (0.53) GRM2CARM1PRMT6HTR7
SCHEMBL9844072 0.90 GRM2 (0.53) GRM2CARM1PRMT6HTR7
SCHEMBL9678427 0.89 GRM2 (0.63) GRM2CARM1PRMT6
SCHEMBL9844422 0.89 GRM2 (0.55) GRM2CARM1PRMT6SLC6A4HTR7
SCHEMBL9844267 0.88 GRM2 (0.50) GRM2CARM1PRMT6SLC6A2SLC6A4
SCHEMBL9844101 0.88 GRM2 (0.64) GRM2CARM1PRMT6SLC6A2SLC6A4
SCHEMBL9844309 0.86 CARM1 (0.45) GRM2CARM1PRMT6
SCHEMBL9844023 0.84 SLC6A2 (0.48) GRM2CARM1PRMT6BCHESLC6A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0443197-A2 Oxazolidinones MERCK PATENT GmbH (DE) 1991-08-28 EP disclosed