Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 12/20 | 0.43 |
| ▸ | CCR3 | P51677 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 3/20 | 0.41 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9844709 | 1.00 | SIGMAR1 (0.44) | SIGMAR1ACHECCR3BACE1BCHE | |
| SCHEMBL4508006 | 0.76 | ACHE (0.52) | ACHEBACE1 | |
| SCHEMBL4508009 | 0.76 | ACHE (0.52) | ACHEBACE1 | |
| SCHEMBL4508014 | 0.76 | ACHE (0.52) | ACHEBACE1 | |
| SCHEMBL6711185 | 0.70 | HTR2A (0.69) | SIGMAR1DRD4 | |
| Hydrochloric Acid SCHEMBL8986182 | 0.70 | HTR2A (0.54) | SIGMAR1 | |
| SCHEMBL9253215 | 0.68 | ACHE (0.47) | SIGMAR1ACHECCR3BACE1DRD2 | |
| SCHEMBL9844725 | 0.67 | CCR3 (0.54) | SIGMAR1ACHECCR3DRD2DRD4 | |
| SCHEMBL8326482 | 0.67 | HRH3 (0.41) | ACHEBCHEDRD2DRD3 | |
| SCHEMBL8326486 | 0.67 | HRH3 (0.41) | ACHEBCHEDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0441517-A2 | Tricyclic amines as novel cholinesterase inhibitors | PFIZER INC. (US) | 1991-08-14 | — | — | EP | disclosed |