Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAOA | P21397 | 5/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PGAM1 | P18669 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NQO1 | P15559 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16500762 | 0.72 | KDM4E (0.40) | KDM4EALDH1A1MAOACYP3A4HPGD | |
| SCHEMBL23430369 | 0.71 | KDM4E (0.36) | KDM4EALDH1A1MAOACYP3A4HPGD | |
| SCHEMBL20982285 | 0.69 | CA1 (0.35) | KDM4EALDH1A1MAOACYP3A4HPGD | |
| SCHEMBL1954260 | 0.68 | MAOA (0.55) | KDM4EALDH1A1MAOACYP3A4HPGD | |
| SCHEMBL7663118 | 0.67 | MAOA (0.48) | KDM4EALDH1A1MAOACYP3A4HPGD | |
| SCHEMBL21479663 | 0.67 | MAOA (0.53) | KDM4EALDH1A1MAOACYP3A4HPGD | |
| SCHEMBL19723827 | 0.66 | ALDH1A1 (0.48) | KDM4EALDH1A1MAOACYP3A4HPGD | |
| SCHEMBL15679079 | 0.64 | TAAR1 (0.35) | KDM4EALDH1A1MAOACYP3A4HPGD | |
| SCHEMBL21101340 | 0.63 | ALDH1A1 (0.35) | KDM4EALDH1A1MAOACYP3A4HPGD | |
| SCHEMBL3287319 | 0.63 | PAX8 (0.38) | KDM4EALDH1A1HPGDGLAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420571-A2 | 6-and/or 7-substituted -1,2,3,4,4A,9B-hexahydro-8-hydroxydibenzofuran-3-ols as inhibitors of leukotriene biosynthesis | MERCK & CO. INC. (US) | 1991-04-03 | — | — | EP | disclosed |
| US-4978679-A | 6- and/or 7-substituted-1,2,3,4,4A,9B-hexahydro-8-hydroxydibenzofuran-3-ols as inhibitors of leukotriene biosynthesis | MERCK & CO., INC. (US) | 1990-12-18 | — | — | US | disclosed |