Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 3/20 | 0.51 |
| ▸ | DHFR | P00374 | 6/20 | 0.50 |
| ▸ | TYMS | P04818 | 3/20 | 0.50 |
| ▸ | ATIC | P31939 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9844829 | 0.95 | DHFR (0.51) | GARTDHFRTYMSATIC | |
| SCHEMBL9844885 | 0.82 | ATIC (0.51) | GARTDHFRTYMSATIC | |
| SCHEMBL9844754 | 0.82 | ATIC (0.51) | GARTDHFRTYMSATIC | |
| SCHEMBL9844741 | 0.81 | GART (0.60) | GARTDHFRTYMSATIC | |
| SCHEMBL9844755 | 0.80 | GART (0.57) | GARTDHFRTYMSATIC | |
| SCHEMBL9844814 | 0.79 | DHFR (0.52) | GARTDHFRTYMSATIC | |
| Lometrexol SCHEMBL9045915 | 0.78 | GART (0.75) | GARTDHFRTYMSATIC | |
| Lometrexol SCHEMBL12022771 | 0.78 | GART (0.75) | GARTDHFRTYMSATIC | |
| SCHEMBL9844774 | 0.78 | GART (0.55) | GARTDHFRTYMSATIC | |
| SCHEMBL8698352 | 0.77 | GART (0.64) | GARTDHFRTYMSATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0438261-A2 | Condensed heterocyclic glutamic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-07-24 | — | — | EP | claimed |
| EP-0438261-A2 | Condensed heterocyclic glutamic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-07-24 | — | — | EP | disclosed |