Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 6/20 | 0.52 |
| ▸ | GART | P22102 | 3/20 | 0.51 |
| ▸ | TYMS | P04818 | 2/20 | 0.49 |
| ▸ | ATIC | P31939 | 4/20 | 0.49 |
| ▸ | SHMT1 | P34896 | 2/20 | 0.48 |
| ▸ | SHMT2 | P34897 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9844885 | 0.95 | ATIC (0.51) | DHFRGARTTYMSATIC | |
| SCHEMBL9844754 | 0.95 | ATIC (0.51) | DHFRGARTTYMSATIC | |
| SCHEMBL9844789 | 0.91 | GART (0.48) | DHFRGARTTYMSATICSHMT1 | |
| SCHEMBL9844836 | 0.87 | DHFR (0.47) | DHFRGARTATICSHMT1SHMT2 | |
| SCHEMBL9844816 | 0.86 | DHFR (0.42) | DHFRGARTTYMS | |
| SCHEMBL9844812 | 0.86 | DHFR (0.42) | DHFRGARTTYMS | |
| SCHEMBL9844879 | 0.86 | ATIC (0.48) | DHFRGARTTYMSATIC | |
| SCHEMBL9844818 | 0.85 | DHFR (0.54) | DHFRGARTATICSHMT1SHMT2 | |
| SCHEMBL9844822 | 0.84 | TBXAS1 (0.37) | — | |
| SCHEMBL8997205 | 0.83 | GART (0.60) | DHFRGARTTYMSATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0438261-A2 | Condensed heterocyclic glutamic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-07-24 | — | — | EP | claimed |
| EP-0438261-A2 | Condensed heterocyclic glutamic acid derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1991-07-24 | — | — | EP | disclosed |