Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.38 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 1/20 | 0.32 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846298 | 0.91 | PDE3B (0.38) | PDE3BPDE3ACRHR1MAPTKDM4E | |
| SCHEMBL9682064 | 0.87 | MAPT (0.34) | CRHR1MAPTKDM4EAPAF1RECQL | |
| SCHEMBL9846175 | 0.86 | PDE3B (0.38) | PDE3BPDE3AMAPTKDM4EAPAF1 | |
| SCHEMBL9168694 | 0.82 | PDE3B (0.42) | PDE3BPDE3AMAPTKDM4EAPAF1 | |
| SCHEMBL9846183 | 0.81 | RXFP1 (0.38) | PDE3BPDE3AMAPTKDM4EAPAF1 | |
| SCHEMBL9846165 | 0.81 | PDE3B (0.41) | PDE3BPDE3AMAPTKDM4EAPAF1 | |
| SCHEMBL9846246 | 0.78 | MAPT (0.34) | MAPTKDM4EAPAF1RECQLGAA | |
| SCHEMBL9680359 | 0.78 | MAPT (0.34) | MAPTKDM4EAPAF1RECQLGAA | |
| SCHEMBL9170296 | 0.76 | KDM4E (0.44) | PDE3BPDE3AMAPTKDM4EAPAF1 | |
| SCHEMBL9846107 | 0.75 | PDE3B (0.41) | PDE3BPDE3AMAPTKDM4EAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0462800-A2 | Inhibitors of HIV reverse transcriptase | MERCK & CO. INC. (US) | 1991-12-27 | — | — | EP | disclosed |