Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10559419 | 0.80 | LMNA (0.45) | LMNASMN1; SMN2NFE2L2ELANEPTGS2 | |
| SCHEMBL28479379 | 0.80 | ELANE (0.61) | LMNASMN1; SMN2NFE2L2ELANEPTGS2 | |
| SCHEMBL27593422 | 0.79 | LMNA (0.41) | LMNASMN1; SMN2NFE2L2ELANEPTGS2 | |
| SCHEMBL3375397 | 0.78 | CA2 (0.50) | LMNASMN1; SMN2NFE2L2ELANEPTGS2 | |
| SCHEMBL30616021 | 0.78 | SLC22A6 (0.46) | LMNASMN1; SMN2NFE2L2ELANEPTGS2 | |
| SCHEMBL196248 | 0.78 | NFE2L2 (0.47) | LMNASMN1; SMN2NFE2L2ELANEPTGS2 | |
| SCHEMBL5728043 | 0.78 | SLC22A6 (0.46) | LMNASMN1; SMN2NFE2L2ELANEPTGS2 | |
| SCHEMBL31265222 | 0.78 | PTGS2 (0.43) | LMNASMN1; SMN2NFE2L2ELANEPTGS2 | |
| SCHEMBL5599422 | 0.78 | PTGS2 (0.43) | LMNASMN1; SMN2NFE2L2ELANEPTGS2 | |
| SCHEMBL27740459 | 0.77 | NFE2L2 (0.46) | LMNASMN1; SMN2NFE2L2ELANEPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0450487-A1 | Benzoxazine derivatives, method for their preparation and their use for treating or prophylaxis of diseases | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-09 | — | — | EP | claimed |
| EP-0450487-A1 | Benzoxazine derivatives, method for their preparation and their use for treating or prophylaxis of diseases | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-09 | — | — | EP | disclosed |