Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 18/20 | 0.48 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846756 | 0.86 | NR1H2 (0.48) | NR1H2NR1H3CA12CA9BRD4 | |
| SCHEMBL9846776 | 0.81 | CCNB2 (0.42) | NR1H2NR1H3 | |
| SCHEMBL9846773 | 0.79 | AGTR1 (0.45) | NR1H2NR1H3 | |
| SCHEMBL21629686 | 0.72 | NR1H2 (0.40) | NR1H2NR1H3CA12CA9BRD4 | |
| SCHEMBL903507 | 0.72 | NR1H2 (0.44) | NR1H2 | |
| SCHEMBL23320505 | 0.72 | CYP19A1 (0.59) | NR1H2NR1H3 | |
| SCHEMBL16030138 | 0.71 | NR1H2 (0.47) | NR1H2NR1H3CA12CA9 | |
| SCHEMBL2875418 | 0.71 | NR1H2 (0.51) | NR1H2NR1H3CA12CA9 | |
| SCHEMBL29540854 | 0.70 | MAPT (0.43) | NR1H2NR1H3BRD4 | |
| SCHEMBL12042731 | 0.70 | CYP4F2 (0.43) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0429257-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1991-05-29 | — | — | EP | disclosed |