Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 15/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | ALPL | P05186 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846769 | 0.86 | NR1H2 (0.48) | NR1H2CA12CA9BRD4CREBBP | |
| SCHEMBL9846744 | 0.80 | NR1H2 (0.52) | NR1H2CA12CA9BRD4CREBBP | |
| SCHEMBL9846763 | 0.80 | NR1H2 (0.51) | NR1H2BRD4CREBBPNR1H3MAPT | |
| SCHEMBL8820122 | 0.79 | NR1H2 (0.62) | NR1H2NR1H3 | |
| SCHEMBL9846733 | 0.78 | CCNB2 (0.44) | MAOBMEN1NPC1ALPLMAPT | |
| SCHEMBL21629686 | 0.77 | NR1H2 (0.40) | NR1H2CA12CA9BRD4CREBBP | |
| SCHEMBL21657872 | 0.75 | NR1H2 (0.52) | NR1H2CA12CA9BRD4CREBBP | |
| SCHEMBL9846773 | 0.75 | AGTR1 (0.45) | NR1H2NR1H3MAPTRAB9A | |
| SCHEMBL903507 | 0.75 | NR1H2 (0.44) | NR1H2ATRATRIPNPC1MAPT | |
| SCHEMBL23320505 | 0.75 | CYP19A1 (0.59) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0429257-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1991-05-29 | — | — | EP | disclosed |