Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.35 |
| ▸ | MDH2 | P40926 | 2/20 | 0.35 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 2/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.33 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.33 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8544344 | 0.78 | AGTR1 (0.35) | AGTR1 | |
| SCHEMBL8544342 | 0.78 | AGTR1 (0.35) | NPC1MEN1POLBKMT2AAGTR1 | |
| SCHEMBL9311096 | 0.76 | AGTR1 (0.33) | AGTR1 | |
| SCHEMBL9859335 | 0.75 | ABCG2 (0.34) | AGTR1 | |
| SCHEMBL4638846 | 0.74 | ABCG2 (0.46) | NPC1POLBAGTR1MAPTRAB9A | |
| SCHEMBL9311085 | 0.74 | FGFR1 (0.38) | NPC1MEN1POLBKMT2AAGTR1 | |
| SCHEMBL9135278 | 0.73 | AGTR1 (0.34) | AGTR1LMNAALDH1A1 | |
| SCHEMBL2161550 | 0.73 | ABCG2 (0.41) | NPC1POLBKMT2AAGTR1MAPT | |
| SCHEMBL9309617 | 0.72 | MAPT (0.34) | NPC1MEN1POLBKMT2AAGTR1 | |
| SCHEMBL8912878 | 0.72 | LMNA (0.40) | NPC1MEN1KMT2AAGTR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0429257-A2 | Indole derivatives | GLAXO GROUP LIMITED (GB) | 1991-05-29 | — | — | EP | disclosed |