Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 2/20 | 0.33 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | ALPG | P10696 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
| ▸ | PPOX | P50336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846695 | 0.80 | BACE1 (0.34) | MAPK1ALDH1A1HPGD | |
| SCHEMBL9846702 | 0.78 | AHR (0.36) | AHRMAPK1IDO1PPOX | |
| SCHEMBL9846738 | 0.72 | LMNA (0.33) | NPC1ALDH1A1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL13172449 | 0.66 | BACE1 (0.42) | NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9377301 | 0.62 | AHR (0.34) | AHRSMN1; SMN2 | |
| SCHEMBL2433995 | 0.62 | PPOX (0.41) | AHRALDH1A1HPGDPPOX | |
| SCHEMBL10651368 | 0.60 | PSEN1 (0.40) | AHRALPG | |
| SCHEMBL17107457 | 0.59 | ALPG (0.33) | AHRMAPK1ALPG | |
| SCHEMBL9372439 | 0.59 | ABCC9 (0.39) | — | |
| SCHEMBL69403 | 0.59 | MAPT (0.67) | NPC1ALDH1A1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0450487-A1 | Benzoxazine derivatives, method for their preparation and their use for treating or prophylaxis of diseases | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-10-09 | — | — | EP | disclosed |