Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TOP2A | P11388 | 3/20 | 0.39 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 5/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9846845 | 1.00 | ALDH1A1 (0.39) | ALDH1A1TOP2ATOP2BMAPTTDP1 | |
| SCHEMBL9846838 | 1.00 | ALDH1A1 (0.39) | ALDH1A1TOP2ATOP2BMAPTTDP1 | |
| SCHEMBL4788789 | 0.92 | TOP2A (0.41) | ALDH1A1TOP2ATOP2BMAPTTDP1 | |
| SCHEMBL4788784 | 0.92 | TOP2A (0.41) | ALDH1A1TOP2ATOP2BMAPTTDP1 | |
| SCHEMBL9139881 | 0.92 | TOP2A (0.41) | ALDH1A1TOP2ATOP2BMAPTTDP1 | |
| SCHEMBL9139167 | 0.82 | TOP2A (0.41) | ALDH1A1TOP2ATOP2BMAPTTDP1 | |
| SCHEMBL9139155 | 0.82 | TOP2A (0.41) | ALDH1A1TOP2ATOP2BMAPTTDP1 | |
| SCHEMBL14529652 | 0.78 | OPRM1 (0.41) | ALDH1A1TOP2ATOP2BMAPTTDP1 | |
| SCHEMBL8518182 | 0.75 | TOP2A (0.40) | ALDH1A1TOP2ATOP2BMAPTTDP1 | |
| SCHEMBL13103999 | 0.70 | ALDH1A1 (0.33) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150038480-A1 | COMPOUNDS THAT MODULATE AUTOIMMUNITY AND METHODS OF USING THE SAME | UNIVERSITY OF FLORIDA RESERCH FOUNDATION INCORPORTED (US) | 2015-02-05 | — | — | US | claimed |
| WO-2012162697-A1 | COMPOUNDS THAT MODULATE AUTOIMMUNITY AND METHODS OF USING THE SAME | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2012-11-29 | — | — | WO | claimed |
| US-9629848-B2 | Compounds that modulate autoimmunity and methods of using the same | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2017-04-25 | — | — | US | disclosed |
| US-9629848-B2 | Compounds that modulate autoimmunity and methods of using the same | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2017-04-25 | — | — | US | disclosed |
| US-9629848-B2 | Compounds that modulate autoimmunity and methods of using the same | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2017-04-25 | — | — | US | disclosed |
| US-20150038480-A1 | COMPOUNDS THAT MODULATE AUTOIMMUNITY AND METHODS OF USING THE SAME | UNIVERSITY OF FLORIDA RESERCH FOUNDATION INCORPORTED (US) | 2015-02-05 | — | — | US | disclosed |
| US-20150038480-A1 | COMPOUNDS THAT MODULATE AUTOIMMUNITY AND METHODS OF USING THE SAME | UNIVERSITY OF FLORIDA RESERCH FOUNDATION INCORPORTED (US) | 2015-02-05 | — | — | US | disclosed |
| US-20150038480-A1 | COMPOUNDS THAT MODULATE AUTOIMMUNITY AND METHODS OF USING THE SAME | UNIVERSITY OF FLORIDA RESERCH FOUNDATION INCORPORTED (US) | 2015-02-05 | — | — | US | disclosed |
| WO-2012162697-A1 | COMPOUNDS THAT MODULATE AUTOIMMUNITY AND METHODS OF USING THE SAME | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2012-11-29 | — | — | WO | disclosed |
| EP-0409499-A2 | Pharmaceutical compositions | BTG INTERNATIONAL LIMITED (GB) | 1991-01-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150038480-A1 | COMPOUNDS THAT MODULATE AUTOIMMUNITY AND METHODS OF USING THE SAME | HLA-DRB1, IAPP, CD74 | ALDH1A1 3356/4885TOP2A 3177/4885TOP2B 2952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.