SCHEMBL984690

SCHEMBL984690

CCOC=C(CC)C(=O)C(=O)O

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
FFAR3 O14843 1/20 0.32
SOAT1 P35610 1/20 0.31
HCAR2 Q8TDS4 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27043 0.86 FFAR3 (0.35) FFAR3SOAT1HCAR2
SCHEMBL27044 0.86 FFAR3 (0.35) FFAR3SOAT1HCAR2
SCHEMBL3555075 0.86 FFAR3 (0.35) FFAR3SOAT1HCAR2
SCHEMBL18044751 0.78
SCHEMBL27798806 0.77 MGAM (0.30) SOAT1
SCHEMBL12801028 0.76 HCAR2 (0.31) HCAR2
SCHEMBL9901309 0.76 ALDH1A1 (0.33) HCAR2
SCHEMBL8832097 0.76 EP300 (0.33) HCAR2
SCHEMBL9901307 0.76 ALDH1A1 (0.33) HCAR2
SCHEMBL12737271 0.74 NPSR1 (0.42) SOAT1HCAR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210101885-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR ARENA PHARMACEUTICALS, INC. 2021-04-08 US disclosed
US-10787437-B2 Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor ARENA PHARMACEUTICALS, INC. (US) 2020-09-29 US disclosed
US-20190023691-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR ARENA PHARMACEUTICALS, INC. 2019-01-24 US disclosed
US-10059691-B2 Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor ARENA PHARMACEUTICALS, INC. (US) 2018-08-28 US disclosed
US-20170137408-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR ARENA PHARMACEUTICALS, INC. 2017-05-18 US disclosed
US-9556149-B2 Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor ARENA PHARMACEUTICALS, INC. (US) 2017-01-31 US disclosed
US-20150045372-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR ARENA PHARMACEUTICALS, INC. 2015-02-12 US disclosed
US-20110021538-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR ARENA PHARMACEUTICALS, INC. (US) 2011-01-27 US disclosed
WO-2009123714-A2 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR ARENA PHARMACEUTICALS, INC. (US) 2009-10-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10787437-B2 Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor HTR5A, HTR2A, HTR3A FFAR3 192/4885SOAT1 3364/4885HCAR2 138/4885
US-20150045372-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR HTR5A, HTR2A, HTR3A FFAR3 192/4885SOAT1 3364/4885HCAR2 138/4885
US-20170137408-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR HTR5A, HTR2A, HTR3A FFAR3 192/4885SOAT1 3364/4885HCAR2 138/4885
US-20210101885-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR HTR5A, HTR2A, HTR3A FFAR3 192/4885SOAT1 3364/4885HCAR2 138/4885
US-20190023691-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR HTR5A, HTR2A, HTR3A FFAR3 192/4885SOAT1 3364/4885HCAR2 138/4885
US-20110021538-A1 PROCESSES FOR THE PREPARATION OF PYRAZOLE DERIVATIVES USEFUL AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR HTR5A, HTR2A, HTR3A FFAR3 192/4885SOAT1 3364/4885HCAR2 138/4885
US-10059691-B2 Processes for the preparation of pyrazole derivatives useful as modulators of the 5-HT2A serotonin receptor HTR5A, HTR2A, HTR3A FFAR3 192/4885SOAT1 3364/4885HCAR2 138/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.