SCHEMBL9847140

SCHEMBL9847140

NNc1ncc(Cl)c(Cl)n1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.40
LMNA P02545 2/20 0.40
ALDH1A1 P00352 1/20 0.40
GAA P10253 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40
KDM5A P29375 1/20 0.33
JMJD1C Q15652 1/20 0.33
KDM3A Q9Y4C1 1/20 0.33
AURKA O14965 1/20 0.33
LRRK2 Q5S007 2/20 0.33
JAK2 O60674 1/20 0.33
STK17A Q9UEE5 3/20 0.32
IGF1R P08069 1/20 0.32
BCL6 P41182 1/20 0.31
MEN1 O00255 1/20 0.31
POLB P06746 1/20 0.31
MAPT P10636 1/20 0.31
KMT2A Q03164 1/20 0.31
STK17B O94768 1/20 0.30
ATM Q13315 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20267532 0.80 KDM4E (0.43) KDM4ELMNAALDH1A1GAAL3MBTL1
SCHEMBL7035592 0.71 ATM (0.30) AURKAATM
SCHEMBL1935467 0.71 MAPK1 (0.47) ALDH1A1
SCHEMBL15360097 0.70
SCHEMBL1937104 0.69 MKNK1 (0.52) KDM4EGAABCL6KMT2A
SCHEMBL9233515 0.69 ALDH1A1 (0.45) KDM4EALDH1A1GAAL3MBTL1STK17A
SCHEMBL810771 0.69
SCHEMBL29372810 0.67
SCHEMBL155314 0.67
SCHEMBL22673752 0.66 JAK2 (0.30) LRRK2JAK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0457140-A2 Phenoxyphenyl sulfonyl compounds BAYER AG (DE) 1991-11-21 EP disclosed