Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8853818 | 0.89 | MEN1 (0.42) | LMNASMN1; SMN2C5AR1MEN1KMT2A | |
| SCHEMBL7512821 | 0.84 | MEN1 (0.38) | LMNASMN1; SMN2MEN1KMT2ATP53 | |
| SCHEMBL10387714 | 0.82 | LMNA (0.38) | LMNASMN1; SMN2MEN1KMT2ACYP2D6 | |
| SCHEMBL6244165 | 0.82 | LMNA (0.38) | LMNASMN1; SMN2MEN1KMT2ACYP2D6 | |
| SCHEMBL7719548 | 0.78 | S100B (0.50) | LMNASMN1; SMN2MEN1KMT2ACYP2C9 | |
| SCHEMBL2137159 | 0.78 | S100B (0.50) | LMNASMN1; SMN2MEN1KMT2ACYP2C9 | |
| Sulfuric Acid SCHEMBL9555436 | 0.76 | CD44 (0.38) | LMNAMEN1KMT2AESR1CYP2D6 | |
| Sulfuric Acid SCHEMBL9680107 | 0.76 | MEN1 (0.38) | LMNAMEN1KMT2AESR1CYP2C9 | |
| SCHEMBL11291623 | 0.75 | ALDH1A1 (0.50) | LMNASMN1; SMN2C5AR1KMT2ACYP2D6 | |
| SCHEMBL11344399 | 0.74 | CNR2 (0.40) | LMNASMN1; SMN2MEN1KMT2ACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0425258-A1 | Method for processing light-sensitive silver halide photographic material | KONICA CORPORATION (JP) | 1991-05-02 | — | — | EP | claimed |
| EP-0383354-A2 | Silver halide photographic material | KONICA CORPORATION (JP) | 1990-08-22 | — | — | EP | disclosed |