Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | RARB | P10826 | 9/20 | 0.44 |
| ▸ | RARG | P13631 | 9/20 | 0.44 |
| ▸ | RARA | P10276 | 7/20 | 0.44 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.44 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.44 |
| ▸ | RXRA | P19793 | 7/20 | 0.44 |
| ▸ | RXRB | P28702 | 7/20 | 0.44 |
| ▸ | RXRG | P48443 | 6/20 | 0.44 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL548244 | 0.79 | KDM4E (0.50) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL25367710 | 0.78 | RARA (0.33) | MAPTRARBRARGRARARXRA | |
| SCHEMBL9116780 | 0.77 | MAPT (0.50) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL12619017 | 0.77 | ALDH1A1 (0.53) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL1506790 | 0.72 | RXRA (0.50) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL5320647 | 0.72 | RXRA (0.47) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL18213884 | 0.71 | KDM4E (0.60) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL14173250 | 0.71 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL17551922 | 0.71 | KDM4E (0.60) | ALDH1A1KDM4EMAPTPOLBBLM | |
| SCHEMBL2815307 | 0.71 | ALDH1A1 (0.47) | ALDH1A1KDM4EMAPTPOLBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0410358-A1 | Aromatic carboxylic acid amides, their preparation and their use as medicines | F. HOFFMANN-LA ROCHE AG (CH) | 1991-01-30 | — | — | EP | disclosed |