Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9025439 | 0.79 | KDM4E (0.33) | KDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL9025829 | 0.78 | MAPT (0.42) | AHRKDM4EALDH1A1GAAMAPT | |
| SCHEMBL9025798 | 0.78 | CHRNB2 (0.34) | KDM4EALDH1A1MAPTTSHRHSD17B10 | |
| SCHEMBL9026293 | 0.77 | TUBB4A (0.43) | — | |
| SCHEMBL9686806 | 0.75 | TAS1R3 (0.38) | KDM4EALDH1A1GAAMAPTHIF1A | |
| SCHEMBL9160957 | 0.74 | SMN1; SMN2 (0.33) | KDM4ETSHRHSD17B10 | |
| SCHEMBL9027577 | 0.73 | MAPT (0.41) | KDM4EALDH1A1MAPTTSHRL3MBTL1 | |
| SCHEMBL9026790 | 0.73 | AHR (0.43) | AHRKDM4EALDH1A1MAPTLMNA | |
| SCHEMBL9026919 | 0.72 | AKR1C2 (0.45) | KDM4EALDH1A1GAAMAPTTSHR | |
| SCHEMBL9026223 | 0.72 | PCSK9 (0.39) | AHRMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0411150-A1 | INDOLE DERIVATIVES, PREPARATION THEREOF, AND DRUG FOR PREVENTING AND TREATING NEPHRITIS CONTAINING SAME | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-02-06 | — | — | EP | claimed |