Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | TUBB4A | P04350 | 3/20 | 0.33 |
| ▸ | TUBB | P07437 | 3/20 | 0.33 |
| ▸ | TUBA3C | P0DPH7 | 3/20 | 0.33 |
| ▸ | TUBA1B | P68363 | 3/20 | 0.33 |
| ▸ | TUBA4A | P68366 | 3/20 | 0.33 |
| ▸ | TUBB4B | P68371 | 3/20 | 0.33 |
| ▸ | TUBB3 | Q13509 | 3/20 | 0.33 |
| ▸ | TUBB2A | Q13885 | 3/20 | 0.33 |
| ▸ | TUBB8 | Q3ZCM7 | 3/20 | 0.33 |
| ▸ | TUBA3E | Q6PEY2 | 3/20 | 0.33 |
| ▸ | TUBA1A | Q71U36 | 3/20 | 0.33 |
| ▸ | TUBA1C | Q9BQE3 | 3/20 | 0.33 |
| ▸ | TUBB6 | Q9BUF5 | 3/20 | 0.33 |
| ▸ | TUBB2B | Q9BVA1 | 3/20 | 0.33 |
| ▸ | TUBB1 | Q9H4B7 | 3/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687418 | 0.91 | POLB (0.34) | SMN1; SMN2PTGS2TUBB4ATUBBTUBA3C | |
| SCHEMBL9159345 | 0.88 | PTGS2 (0.38) | SMN1; SMN2PTGS2TUBB4ATUBBTUBA3C | |
| SCHEMBL9164191 | 0.88 | TUBB1 (0.37) | SMN1; SMN2PTGS2TUBB4ATUBBTUBA3C | |
| SCHEMBL9687366 | 0.78 | PDE2A (0.41) | SMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL9687454 | 0.70 | MEN1 (0.39) | KMT2AKDM4EMEN1HSD17B10 | |
| SCHEMBL9025791 | 0.68 | KMT2A (0.36) | SMN1; SMN2KMT2AMEN1CA12CA1 | |
| SCHEMBL9471009 | 0.67 | CREBBP (0.36) | SMN1; SMN2KMT2AKDM4EMEN1HSD17B10 | |
| SCHEMBL5572443 | 0.66 | PTGS2 (0.59) | PTGS2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL8910416 | 0.62 | PTGS2 (0.70) | PTGS2TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL9688966 | 0.61 | LIPG (0.34) | SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459142-A | Autoimmune disease, atherosclerosis, antiischemic agents and nephritis | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0511879-B1 | Pyrazine derivatives | OTSUKA PHARMA CO LTD (JP) | 1995-03-22 | — | — | EP | disclosed |
| EP-0511879-A1 | Pyrazine derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |