Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 8/20 | 0.44 |
| ▸ | PLAT | P00750 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | APAF1 | O14727 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 4/20 | 0.35 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | ITK | Q08881 | 1/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.33 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.33 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849325 | 0.90 | PLAU (0.43) | PLAUPLATKDM4EAPAF1NSD2 | |
| SCHEMBL9849202 | 0.75 | PLAU (0.40) | PLAUPLATKDM4EAPAF1NSD2 | |
| SCHEMBL6027557 | 0.73 | PLAU (0.64) | PLAUPLATKDM4EAPAF1NSD2 | |
| SCHEMBL16246728 | 0.72 | PLAU (0.38) | PLAUPLATKDM4EAPAF1NSD2 | |
| SCHEMBL9849204 | 0.71 | PLAU (0.40) | PLAUPLATKDM4EAPAF1NSD2 | |
| SCHEMBL9849130 | 0.71 | PLAU (0.38) | PLAUPLATKDM4EAPAF1NSD2 | |
| SCHEMBL111310 | 0.70 | CNR2 (0.53) | PLAUKDM4EPLG | |
| SCHEMBL29358323 | 0.70 | CNR2 (0.53) | PLAUKDM4EPLG | |
| SCHEMBL9849287 | 0.70 | PLAU (0.40) | PLAUPLATKDM4EL3MBTL1BRAF | |
| SCHEMBL755949 | 0.69 | PLAU (0.57) | PLAUKDM4EAPAF1NSD2CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | claimed |
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |