Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 7/20 | 0.38 |
| ▸ | PLG | P00747 | 4/20 | 0.37 |
| ▸ | PLAT | P00750 | 2/20 | 0.37 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 2/20 | 0.36 |
| ▸ | NSD2 | O96028 | 2/20 | 0.36 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5731210 | 0.88 | IGFBP3 (0.36) | PLAUIGFBP3APAF1NSD2CASP3 | |
| SCHEMBL6027557 | 0.76 | PLAU (0.64) | PLAUPLGPLATIGFBP3APAF1 | |
| SCHEMBL9849130 | 0.74 | PLAU (0.38) | PLAUPLGPLATIGFBP3APAF1 | |
| SCHEMBL111310 | 0.73 | CNR2 (0.53) | PLAUPLGKDM4ECNR2HDAC3 | |
| SCHEMBL29358323 | 0.73 | CNR2 (0.53) | PLAUPLGKDM4ECNR2HDAC3 | |
| SCHEMBL9849320 | 0.72 | PLAU (0.44) | PLAUPLGPLATIGFBP3APAF1 | |
| Naphthalene SCHEMBL10758679 | 0.71 | CNR2 (0.51) | PLAUPLGKDM4ECNR2HDAC3 | |
| Hydrochloric Acid SCHEMBL4433615 | 0.71 | CNR2 (0.51) | PLAUPLGKDM4ECNR2HDAC3 | |
| SCHEMBL28236570 | 0.71 | KDM4E (0.49) | PLAUL3MBTL1KDM4EMAP2K3LCK | |
| SCHEMBL28198741 | 0.71 | CNR2 (0.51) | PLAUPLGKDM4ECNR2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2999697-A1 | HETEROCYCLIC DERIVATES | Kalvista Pharmaceuticals Limited (GB) | 2016-03-30 | — | — | EP | disclosed |
| WO-2014188211-A1 | HETEROCYCLIC DERIVATES | KALVISTA PHARMACEUTICALS LIMITED (GB) | 2014-11-27 | — | — | WO | disclosed |