Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 5/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849204 | 0.91 | PLAU (0.40) | PLAUHDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL9849459 | 0.77 | PLAU (0.42) | PLAUHDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL9849066 | 0.76 | PLAU (0.33) | PLAU | |
| SCHEMBL9849320 | 0.75 | PLAU (0.44) | PLAUPLATAPAF1NSD2CASP3 | |
| SCHEMBL18526638 | 0.73 | RAB9A (0.40) | PLAUHDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL9849325 | 0.71 | PLAU (0.43) | PLAUHDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL9849065 | 0.69 | PLAU (0.34) | PLAU | |
| SCHEMBL6027557 | 0.68 | PLAU (0.64) | PLAUPLATAPAF1NSD2CASP3 | |
| SCHEMBL16246728 | 0.67 | PLAU (0.38) | PLAUHDAC1HDAC6HDAC3HDAC4 | |
| SCHEMBL9849130 | 0.66 | PLAU (0.38) | PLAUHDAC1HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0421436-A2 | Substituted carboxytetrahydroisoquinolines and derivatives thereof having pharmaceutical activity | WARNER-LAMBERT COMPANY (US) | 1991-04-10 | — | — | EP | disclosed |