Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849295 | 0.82 | TSHR (0.55) | TSHRALDH1A1MAPK1CYP19A1GSK3B | |
| SCHEMBL9849636 | 0.79 | TSHR (0.54) | TSHRALDH1A1MAPK1GSK3B | |
| SCHEMBL9849550 | 0.74 | QPCT (0.60) | QPCTMEN1KMT2AATMTSHR | |
| SCHEMBL9849573 | 0.73 | KMT2A (0.49) | QPCTMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL9849881 | 0.71 | GAA (0.55) | MEN1KMT2ATSHRALDH1A1MAPK1 | |
| SCHEMBL10508142 | 0.71 | MEN1 (0.69) | MEN1KMT2AATMTSHRALDH1A1 | |
| SCHEMBL10656540 | 0.69 | MEN1 (0.49) | QPCTMEN1KMT2AATMTSHR | |
| SCHEMBL20701924 | 0.69 | PRKCI (0.53) | QPCTMEN1KMT2ATSHRALDH1A1 | |
| SCHEMBL16067267 | 0.68 | MEN1 (0.49) | QPCTMEN1KMT2AATMALDH1A1 | |
| SCHEMBL5045082 | 0.68 | MEN1 (0.68) | MEN1KMT2AATMTSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0446604-A2 | Pyridine and related aza heterocycle derivatives as cardiovascular agents | AMERICAN CYANAMID COMPANY (US) | 1991-09-18 | — | — | EP | disclosed |