Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 2/20 | 0.42 |
| ▸ | METAP1 | P53582 | 2/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 12/20 | 0.41 |
| ▸ | CCR1 | P32246 | 5/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | CTSE | P14091 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849682 | 1.00 | METAP2 (0.42) | METAP2METAP1PSEN1PSEN2APH1B | |
| SCHEMBL7278377 | 0.86 | PSEN1 (0.46) | METAP2METAP1PSEN1PSEN2APH1B | |
| SCHEMBL7278381 | 0.86 | PSEN1 (0.46) | METAP2METAP1PSEN1PSEN2APH1B | |
| SCHEMBL9725888 | 0.79 | REN (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9749328 | 0.78 | REN (0.53) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9725818 | 0.77 | REN (0.53) | RENCTSDCTSE | |
| SCHEMBL9725812 | 0.77 | REN (0.53) | RENCTSDCTSE | |
| SCHEMBL9725825 | 0.77 | REN (0.53) | RENCTSDCTSE | |
| SCHEMBL9739264 | 0.77 | REN (0.53) | RENCTSDCTSE | |
| SCHEMBL7277030 | 0.76 | REN (0.40) | METAP2METAP1RENCTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0427939-A2 | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1991-05-22 | — | — | EP | disclosed |