Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 4/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.32 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | FAAH | O00519 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9849793 | 0.90 | DAO (0.36) | DHFRHPGDSLC2A1ALDH1A1KDM4E | |
| SCHEMBL9850002 | 0.81 | HPGD (0.40) | DHFRNPSR1HPGDTSHRMAPK1 | |
| SCHEMBL9849931 | 0.81 | HPGD (0.43) | DHFRNPSR1HPGDTSHRMAPK1 | |
| SCHEMBL9849766 | 0.81 | HPGD (0.44) | DHFRNPSR1HPGDTSHRMAPK1 | |
| SCHEMBL9849601 | 0.80 | DHFR (0.31) | DHFR | |
| SCHEMBL9849692 | 0.79 | MRGPRX4 (0.38) | DHFRNPSR1HPGDTSHRMAPK1 | |
| SCHEMBL9849771 | 0.75 | GART (0.41) | DHFR | |
| SCHEMBL10470212 | 0.74 | NPSR1 (0.43) | NPSR1HPGDTSHRMAPK1ATM | |
| SCHEMBL9849802 | 0.72 | DAO (0.37) | DHFR | |
| SCHEMBL9850059 | 0.72 | FOLR2 (0.39) | DHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0415510-A2 | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1991-03-06 | — | — | EP | disclosed |
| US-4920125-A | L-glutamic acid derivatives | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 1990-04-24 | — | — | US | disclosed |