Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sebacic Acid SCHEMBL352890 | 1.00 | LMNA (0.60) | LMNATSHRNFKB1PMP22TP53 | |
| Terephthalic Acid SCHEMBL28178132 | 1.00 | LMNA (0.60) | LMNATSHRNFKB1PMP22TP53 | |
| Octanedioate SCHEMBL29154819 | 1.00 | LMNA (0.60) | LMNATSHRNFKB1PMP22TP53 | |
| Sebacic Acid SCHEMBL30734379 | 1.00 | LMNA (0.60) | LMNATSHRNFKB1PMP22TP53 | |
| Terephthalic Acid SCHEMBL11145819 | 1.00 | LMNA (0.60) | LMNATSHRNFKB1PMP22TP53 | |
| Azelaic Acid SCHEMBL351913 | 1.00 | LMNA (0.60) | LMNATSHRNFKB1PMP22TP53 | |
| Terephthalic Acid SCHEMBL28198648 | 1.00 | LMNA (0.60) | LMNATSHRNFKB1PMP22TP53 | |
| Terephthalic Acid SCHEMBL9859986 | 0.97 | TSHR (0.63) | LMNATSHRNFKB1PMP22TP53 | |
| Terephthalic Acid SCHEMBL17727985 | 0.97 | TSHR (0.63) | LMNATSHRNFKB1PMP22TP53 | |
| Terephthalic Acid SCHEMBL9739994 | 0.97 | TSHR (0.63) | LMNATSHRNFKB1PMP22TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109983056-A | Terminal-modified polyamide | 东丽株式会社 | 2019-07-05 | — | — | CN | disclosed |
| CN-109716011-A | The manufacturing method of hollow molded article and hollow molded article | 东丽株式会社 | 2019-05-03 | — | — | CN | disclosed |
| CN-109311197-A | Polyamide composite molded article and its manufacturing method | 东丽株式会社 | 2019-02-05 | — | — | CN | disclosed |
| CN-106459408-B | The manufacturing method of terminal-modified polyamide, its manufacturing method and molded product | 东丽株式会社 | 2019-01-01 | — | — | CN | disclosed |
| CN-108779271-A | Fibre-reinforced polyamide resin base material, its manufacturing method, molded product and composite molded article comprising it | 东丽株式会社 | 2018-11-09 | — | — | CN | disclosed |
| CN-107531995-A | Resin combination and its products formed | 东丽株式会社 | 2018-01-02 | — | — | CN | disclosed |
| CN-106893097-A | Polyamide resin composition and preparation method thereof | 东丽先端材料研究开发（中国）有限公司 | 2017-06-27 | — | — | CN | disclosed |
| CN-106867002-A | Fiber-reinforced thermoplastic resin products formed, fiber-reinforced thermoplastic resin moulding material and its manufacture method | 东丽株式会社 | 2017-06-20 | — | — | CN | disclosed |
| CN-104870531-B | The manufacture method of fiber-reinforced thermoplastic resin products formed, fiber-reinforced thermoplastic resin moulding material and fiber-reinforced thermoplastic resin moulding material | 东丽株式会社 | 2017-05-31 | — | — | CN | disclosed |
| WO-2013012980-A1 | DEVICE HOUSINGS HAVING EXCELLENT SURFACE APPEARANCE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2013-01-24 | — | — | WO | disclosed |
| US-20130022786-A1 | DEVICE HOUSINGS HAVING EXCELLENT SURFACE APPEARANCE | E I DU PONT DE NEMOURS AND COMPANY (US) | 2013-01-24 | — | — | US | disclosed |
| EP-0451954-A2 | Polyether amides and process for the preparation thereof | Huntsman Corporation (US) | 1991-10-16 | — | — | EP | disclosed |
| US-4505978-A | REACTING AROMATIC DIISOCYANATE OR DIAMINE WITH TEREPHTHALIC ACID MIXTURE CONTAINING DI-AND MONO-CARBOXYLIC ACIDS | SCHENECTADY CHEMICALS, INC. (US) | 1985-03-19 | — | — | US | disclosed |