Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.63 |
| ▸ | TP53 | P04637 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Terephthalic Acid SCHEMBL352170 | 1.00 | TSHR (0.63) | TSHRTP53LMNAHDAC3HDAC4 | |
| Terephthalic Acid SCHEMBL17727985 | 1.00 | TSHR (0.63) | TSHRTP53LMNAHDAC3HDAC4 | |
| Terephthalic Acid SCHEMBL9739994 | 1.00 | TSHR (0.63) | TSHRTP53LMNAHDAC3HDAC4 | |
| Terephthalic Acid SCHEMBL10927542 | 1.00 | TSHR (0.63) | TSHRTP53LMNAHDAC3HDAC4 | |
| Azelaic Acid SCHEMBL351913 | 0.97 | LMNA (0.60) | TSHRTP53LMNAHDAC3HDAC4 | |
| Terephthalic Acid SCHEMBL11145819 | 0.97 | LMNA (0.60) | TSHRTP53LMNAHDAC3HDAC4 | |
| Sebacic Acid SCHEMBL352890 | 0.97 | LMNA (0.60) | TSHRTP53LMNAHDAC3HDAC4 | |
| Terephthalic Acid SCHEMBL869533 | 0.97 | TSHR (0.60) | TSHRTP53LMNAHDAC3HDAC4 | |
| Sebacic Acid SCHEMBL30734379 | 0.97 | LMNA (0.60) | TSHRTP53LMNAHDAC3HDAC4 | |
| Terephthalic Acid SCHEMBL10528457 | 0.97 | TSHR (0.60) | TSHRTP53LMNAHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5023296-A | Blend of hydrolyzed ethylene-vinyl acetate copolymer, polyesters, and polyamideester copolymers | NIPPON GOHSEI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1991-06-11 | — | — | US | disclosed |
| US-4533576-A | METAL FOIL AND THERMOPLASTIC RESIN | TOYO SEIKAN KAISHA LIMITED (JP) | 1985-08-06 | — | — | US | disclosed |
| EP-0101250-A2 | Composite material for packaging containers | TOYO SEIKAN KAISHA LIMITED (JP) | 1984-02-22 | — | — | EP | disclosed |