Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PTPN11 | Q06124 | 5/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.48 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7649628 | 0.88 | CA9 (0.48) | ALDH1A1HPGDSLC6A9PTGDR2 | |
| SCHEMBL943785 | 0.88 | TSHR (0.51) | SLC6A9MRGPRX4PTGDR2KMT2A | |
| SCHEMBL9850808 | 0.87 | MAPT (0.47) | ALDH1A1HPGDSLC6A9PTGDR2KMT2A | |
| SCHEMBL945054 | 0.87 | ALB (0.45) | ALDH1A1HPGDPTPN11S1PR3MRGPRX4 | |
| SCHEMBL4602004 | 0.86 | PTPN11 (0.60) | ALDH1A1HPGDPTPN11PTPN1PTPN6 | |
| SCHEMBL16950716 | 0.85 | SLC6A9 (0.43) | ALDH1A1HPGDSLC6A9PTGDR2KMT2A | |
| SCHEMBL4633432 | 0.83 | HNF4A (0.54) | ALDH1A1PTPN11S1PR3PTPN1PTPN6 | |
| SCHEMBL1809795 | 0.81 | XDH (0.57) | SLC6A9MRGPRX4 | |
| SCHEMBL9850680 | 0.81 | SLC6A9 (0.41) | ALDH1A1HPGDSLC6A9KMT2A | |
| SCHEMBL546183 | 0.80 | AR (0.50) | ALDH1A1HPGDMRGPRX4KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0442204-A2 | Pyrimidopyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1991-08-21 | — | — | EP | disclosed |