Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1010790 | 0.89 | RAPGEF4 (0.56) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL29401670 | 0.89 | RAPGEF4 (0.56) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL30977785 | 0.87 | RAPGEF4 (0.54) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL1012671 | 0.87 | RAPGEF4 (0.54) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL19837651 | 0.85 | RAPGEF4 (0.52) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL9389855 | 0.81 | HTT (0.51) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL17627505 | 0.80 | MEN1 (0.58) | MEN1KMT2AHTTALDH1A1L3MBTL1 | |
| SCHEMBL2091371 | 0.79 | MEN1 (0.71) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL6235537 | 0.78 | ALDH1A1 (0.58) | MEN1KMT2ASMN1; SMN2HTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL6624901 | 0.78 | MEN1 (0.57) | MEN1KMT2AHTTALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0419918-A2 | Substituted 1,3,4-oxa(thia)-diazolinones, process for their preparation and their use in controlling endoparasites | BAYER AG (DE) | 1991-04-03 | — | — | EP | disclosed |