Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.37 |
| ▸ | CEL | P19835 | 1/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7625072 | 0.94 | GPR84 (0.42) | HRH4CYP1A2HRH3CELSIGMAR1 | |
| SCHEMBL8524329 | 0.90 | HRH4 (0.41) | HRH4HRH3CELLMNATSHR | |
| SCHEMBL7971225 | 0.90 | HRH3 (0.40) | HRH4HRH3 | |
| SCHEMBL7976777 | 0.88 | HRH3 (0.38) | HRH4HRH3 | |
| SCHEMBL7977147 | 0.86 | HRH4 (0.38) | HRH4HRH3 | |
| SCHEMBL15139142 | 0.85 | HRH3 (0.51) | HRH4HRH3 | |
| SCHEMBL7618097 | 0.85 | HRH4 (0.33) | HRH4CYP1A2HRH3LMNATSHR | |
| SCHEMBL8115341 | 0.84 | HRH4 (0.34) | HRH4CYP1A2HRH3 | |
| Bromide SCHEMBL15130221 | 0.84 | HRH3 (0.50) | HRH4HRH3 | |
| SCHEMBL4384996 | 0.82 | HRH4 (0.32) | HRH4HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0447188-A2 | 7-Oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasospastic diseases | E.R. SQUIBB & SONS, INC. (US) | 1991-09-18 | — | — | EP | disclosed |
| EP-0403090-A1 | 7-oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasopastic disease | E.R. SQUIBB & SONS, INC. (US) | 1990-12-19 | — | — | EP | disclosed |
| US-4977174-A | Anticoagulants, antischemic agents | E. R. SQUIBB & SONS, INC. (US) | 1990-12-11 | — | — | US | disclosed |