Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16192288 | 0.90 | ALDH1A1 (0.38) | NPC1ALDH1A1SMN1; SMN2RAB9AHTT | |
| SCHEMBL9852268 | 0.87 | NPC1 (0.53) | NPC1ALDH1A1SMN1; SMN2RAB9AHTT | |
| SCHEMBL3759738 | 0.78 | GRM1 (0.49) | NPC1ALDH1A1SMN1; SMN2RAB9AHTT | |
| Hydrochloric Acid SCHEMBL29086117 | 0.76 | KDM1A (0.40) | ALDH1A1SMN1; SMN2HTTMAPTHSD17B10 | |
| SCHEMBL29622479 | 0.75 | RAB9A (0.57) | NPC1ALDH1A1SMN1; SMN2RAB9AHTT | |
| SCHEMBL6757740 | 0.74 | ALDH1A1 (0.45) | NPC1ALDH1A1SMN1; SMN2RAB9AHTT | |
| SCHEMBL16199636 | 0.72 | JAK2 (0.52) | ALDH1A1MAPTHSD17B10KDM1AKMT2A | |
| SCHEMBL3675623 | 0.72 | SMN1; SMN2 (0.38) | NPC1SMN1; SMN2RAB9AHTTMAPT | |
| SCHEMBL17667391 | 0.72 | ADORA3 (0.41) | NPC1SMN1; SMN2RAB9AHTTMAPT | |
| SCHEMBL8567632 | 0.71 | TSHR (0.47) | NPC1ALDH1A1SMN1; SMN2RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10428074-B2 | Pyrrole heteroaryl ring derivative and method of use thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2019-10-01 | — | — | US | disclosed |
| US-20180222912-A1 | PYRROLE HETEROARYL RING DERIVATIVE AND METHOD OF USE THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2018-08-09 | — | — | US | disclosed |
| EP-2796460-B1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | JIANGSU HENGRUI MEDICINE CO (CN) | 2018-07-04 | — | — | EP | disclosed |
| US-20170044171-A1 | COMPOUNDS FOR PREPARING PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE | JIANGSU HENGRUI MEDICINE CO (CN) | 2017-02-16 | — | — | US | disclosed |
| US-9527851-B2 | Pyrrole six-membered heteroaryl ring derivative, preparation method thereof, and medicinal uses thereof | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2016-12-27 | — | — | US | disclosed |
| US-20140336207-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREOF, AND MEDICINAL USES THEREOF | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2014-11-13 | — | — | US | disclosed |
| EP-2796460-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREFOR, AND MEDICINAL USES THEREOF | Jiangsu Hengrui Medicine Co. Ltd. (CN) | 2014-10-29 | — | — | EP | disclosed |
| US-20090325956-A1 | Aromatic amine derivative and use thereof | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2009-12-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222912-A1 | PYRROLE HETEROARYL RING DERIVATIVE AND METHOD OF USE THEREOF | DHFR, PPOX, PAH | NPC1 3825/4885ALDH1A1 1079/4885SMN1; SMN2 4449/4885 |
| US-20090325956-A1 | Aromatic amine derivative and use thereof | SCD, SCD5, SMS | NPC1 57/4885ALDH1A1 1311/4885SMN1; SMN2 2075/4885 |
| US-20170044171-A1 | COMPOUNDS FOR PREPARING PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE | JAK2, JAK1, JAK3 | NPC1 4325/4885ALDH1A1 1980/4885SMN1; SMN2 4633/4885 |
| US-20140336207-A1 | PYRROLE SIX-MEMBERED HETEROARYL RING DERIVATIVE, PREPARATION METHOD THEREOF, AND MEDICINAL USES THEREOF | JAK1, JAK3, JAK2 | NPC1 4194/4885ALDH1A1 2262/4885SMN1; SMN2 4873/4885 |
| US-10428074-B2 | Pyrrole heteroaryl ring derivative and method of use thereof | DHFR, PPOX, PAH | NPC1 3825/4885ALDH1A1 1079/4885SMN1; SMN2 4449/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.