Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8572006 | 0.84 | NPC1 (0.37) | SMN1; SMN2NPC1RAB9APOLBKMT2A | |
| SCHEMBL9852268 | 0.81 | NPC1 (0.53) | SMN1; SMN2NPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL6762411 | 0.80 | ALDH1A1 (0.44) | SMN1; SMN2NPC1RAB9AKMT2ALMNA | |
| SCHEMBL24951752 | 0.79 | ALDH1A1 (0.62) | SMN1; SMN2NPC1RAB9AKMT2ALMNA | |
| SCHEMBL8573205 | 0.78 | ALDH1A1 (0.50) | SMN1; SMN2NPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL8570862 | 0.76 | ADORA3 (0.59) | SMN1; SMN2NPC1RAB9AKMT2ALMNA | |
| SCHEMBL27944608 | 0.75 | ALDH1A1 (0.48) | SMN1; SMN2NPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL24491068 | 0.75 | RAB9A (0.58) | SMN1; SMN2NPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL24952058 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2NPC1RAB9APOLBL3MBTL1 | |
| SCHEMBL24491045 | 0.74 | SMN1; SMN2 (0.41) | SMN1; SMN2NPC1RAB9APOLBL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5705650-A | Process for preparing 1,2,4-thiadiazole derivatives | KATAYAMA SEIYAKUSYO CO., LTD. (JP) | 1998-01-06 | — | — | US | disclosed |
| US-5585494-A | Process for preparing 1,2,4-thiadiazole derivatives | KATAYAMA SEIYAKUSYO CO. LTD. (JP) | 1996-12-17 | — | — | US | disclosed |
| EP-0536900-A2 | Process for preparing 1,2,4-Thiadiazole Derivatives | KATAYAMA SEIYAKUSYO CO. Ltd. (JP) | 1993-04-14 | — | — | EP | disclosed |