SCHEMBL9853133

SCHEMBL9853133

[C](=C/c1ccccc1)\Cc1ccccc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 2/20 0.40
CALM1 P0DP23 1/20 0.38
G6PC1 P35575 1/20 0.36
CYP3A4 P08684 1/20 0.35
CYP2C9 P11712 1/20 0.35
ALDH1A1 P00352 5/20 0.35
TSHR P16473 4/20 0.35
TRPA1 O75762 2/20 0.35
IDO1 P14902 1/20 0.35
TP53 P04637 1/20 0.35
LOXL2 Q9Y4K0 1/20 0.35
CYP2A6 P11509 1/20 0.35
LMNA P02545 2/20 0.34
ALOX5 P09917 1/20 0.34
MAPK1 P28482 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.33
HPGD P15428 1/20 0.33
ALOX15 P16050 1/20 0.33
ALOX12 P18054 1/20 0.33
CASP1 P29466 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1195145 1.00 MAOB (0.40) MAOBCALM1G6PC1CYP3A4CYP2C9
SCHEMBL7380364 0.81 CYP11B2 (0.47) G6PC1CYP3A4CYP2C9LMNAMAPK1
SCHEMBL8673921 0.77 ALDH1A1 (0.41) MAOBALDH1A1TRPA1LOXL2CYP2A6
SCHEMBL4340782 0.77 MAOB (0.36) MAOBCALM1G6PC1CYP3A4CYP2C9
SCHEMBL5573317 0.77 MAOB (0.43) MAOBCALM1CYP3A4ALDH1A1TSHR
SCHEMBL6608385 0.73 TSHR (0.42) MAOBCALM1CYP3A4ALDH1A1TSHR
SCHEMBL1509680 0.73 MAOB (0.42) MAOBALDH1A1TSHRTRPA1TP53
SCHEMBL3808266 0.73 MAOB (0.42) MAOBCYP3A4CYP2C9ALDH1A1TSHR
SCHEMBL8863221 0.73 MAOB (0.42) MAOBCYP2C9ALDH1A1TSHRTRPA1
SCHEMBL5083636 0.73 MAOB (0.42) MAOBALDH1A1TSHRTRPA1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0441226-A1 (cyanomethyl)pyridines useful as PAF antagonists J. URIACH & CIA. S.A. (ES) 1991-08-14 EP disclosed