Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9853133 | 1.00 | MAOB (0.40) | MAOBCALM1G6PC1CYP3A4CYP2C9 | |
| SCHEMBL7380364 | 0.81 | CYP11B2 (0.47) | G6PC1CYP3A4CYP2C9LMNAMAPK1 | |
| SCHEMBL8673921 | 0.77 | ALDH1A1 (0.41) | MAOBALDH1A1TRPA1LOXL2CYP2A6 | |
| SCHEMBL4340782 | 0.77 | MAOB (0.36) | MAOBCALM1G6PC1CYP3A4CYP2C9 | |
| SCHEMBL5573317 | 0.77 | MAOB (0.43) | MAOBCALM1CYP3A4ALDH1A1TSHR | |
| SCHEMBL6608385 | 0.73 | TSHR (0.42) | MAOBCALM1CYP3A4ALDH1A1TSHR | |
| SCHEMBL1509680 | 0.73 | MAOB (0.42) | MAOBALDH1A1TSHRTRPA1TP53 | |
| SCHEMBL3808266 | 0.73 | MAOB (0.42) | MAOBCYP3A4CYP2C9ALDH1A1TSHR | |
| SCHEMBL8863221 | 0.73 | MAOB (0.42) | MAOBCYP2C9ALDH1A1TSHRTRPA1 | |
| SCHEMBL5083636 | 0.73 | MAOB (0.42) | MAOBALDH1A1TSHRTRPA1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 54 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2103692-A1 | Gene manipulation in the human PLK1 gene | Universität Duisburg-Essen (DE) | 2009-09-23 | — | — | EP | claimed |
| CN-113603883-B | Modified polyphenyl ether, preparation method and application in high-frequency circuit board | 珠海宏昌电子材料有限公司 | 2023-01-10 | — | — | CN | disclosed |
| CN-113603883-A | Modified polyphenyl ether, preparation method and application in high-frequency circuit board | 珠海宏昌电子材料有限公司 | 2021-11-05 | — | — | CN | disclosed |
| US-20210107942-A1 | TISSUE PROTECTIVE PEPTIDES AND PEPTIDE ANALOGS FOR PREVENTING AND TREATING DISEASES AND DISORDERS ASSOCIATED WITH TISSUE DAMAGE | ARAIM PHARMACEUTICALS INC (US) | 2021-04-15 | — | — | US | disclosed |
| US-9713597-B2 | Stable aqueous formulation of (E)-4-carboxystyryl-4-chlorobenzyl sulfone | ONCONOVA THERAPEUTICS, INC. (US) | 2017-07-25 | — | — | US | disclosed |
| US-20150265549-A1 | STABLE AQUEOUS FORMULATION OF (E)-4-CARBOXYSTYRYL-4-CHLOROBENZYL SULFONE | ONCONOVA THERAPEUTICS, INC (US) | 2015-09-24 | — | — | US | disclosed |
| US-20150238448-A1 | FORMULATION OF RADIOPROTECTIVE ALPHA, BETA UNSATURATED ARYL SULFONES | ONCONOVA THERAPEUTICS, INC (US) | 2015-08-27 | — | — | US | disclosed |
| US-9060967-B2 | Stable aqueous formulation of (E)-4-carboxystyryl-4-chlorobenzyl sulfone | ONCONOVA THERAPEUTICS, INC (US) | 2015-06-23 | — | — | US | disclosed |
| EP-2552199-B1 | IMPROVED STABLE AQUEOUS FORMULATION OF (E)-4-CARBOXYSTYRYL-4-CHLOROBENZYL SULFONE | ONCONOVA THERAPEUTICS INC (US) | 2015-06-03 | — | — | EP | disclosed |
| US-9044427-B2 | Compositions and methods for prevention and treatment of wounds | ONCONOVA THERAPEUTICS, INC (US) | 2015-06-02 | — | — | US | disclosed |
| US-6642410-B2 | Useful as antiproliferative agents, including, for example, anticancer agents | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2003-11-04 | — | — | US | disclosed |
| EP-1305015-A4 | SUBSTITUTED STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS | UNIV TEMPLE (US) | 2003-05-21 | — | — | EP | disclosed |
| EP-1305015-A1 | SUBSTITUTED STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS | Temple University of the Commonwealth System of Higher Education (US) | 2003-05-02 | — | — | EP | disclosed |
| US-20030060505-A1 | Method for protecting cells and tissues from ionizing radiation toxicity with alpha, beta unsaturated aryl sulfones | ONCONOVA THERAPEUTICS, INC. | 2003-03-27 | — | — | US | disclosed |
| US-20030036536-A1 | Useful as antiproliferative agents, including, for example, anticancer agents | REDDY E PREMKUMAR (US) | 2003-02-20 | — | — | US | disclosed |
| US-6486210-B2 | SUCH AS ENANTIOMORPHS OF 4-FLUOROSTYRYL-2,3,4,5,6-PENTAFLUOROBENZYLSULFONE; ANTIPROLIFERATIVE/ANTICANCER AGENTS | Temple University—Of the Commonwealth System of Higher Education | 2002-11-26 | — | — | US | disclosed |
| WO-2002069892-A2 | METHOD FOR PROTECTING CELLS AND TISSUES FROM IONIZING RADIATION TOXICITY WITH α, β UNSATURATED ARYL SULFONES | TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2002-09-12 | — | — | WO | disclosed |
| US-20020115643-A1 | Substituted styryl benzylsulfones for treating proliferative disorders | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2002-08-22 | — | — | US | disclosed |
| WO-2001078712-A1 | SUBSTITUTED STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2001-10-25 | — | — | WO | disclosed |
| EP-0441226-A1 | (cyanomethyl)pyridines useful as PAF antagonists | J. URIACH & CIA. S.A. (ES) | 1991-08-14 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030036536-A1 | Useful as antiproliferative agents, including, for example, anticancer agents | MKI67, MCL1, CCNA1 | MAOB 4115/4885CALM1 2077/4885G6PC1 1582/4885 |
| US-20030060505-A1 | Method for protecting cells and tissues from ionizing radiation toxicity with alpha, beta unsaturated aryl sulfones | ARSA, SULT2A1, CYP2S1 | MAOB 2545/4885CALM1 4179/4885G6PC1 2711/4885 |
| US-20020115643-A1 | Substituted styryl benzylsulfones for treating proliferative disorders | HCCS, CCNO, HRAS | MAOB 4390/4885CALM1 2788/4885G6PC1 2107/4885 |
| US-20150238448-A1 | FORMULATION OF RADIOPROTECTIVE ALPHA, BETA UNSATURATED ARYL SULFONES | ARSA, AHR, SULT2A1 | MAOB 1564/4885CALM1 2967/4885G6PC1 2129/4885 |
| US-20150265549-A1 | STABLE AQUEOUS FORMULATION OF (E)-4-CARBOXYSTYRYL-4-CHLOROBENZYL SULFONE | TTPA, EBP, ADH1A | MAOB 966/4885CALM1 3086/4885G6PC1 1358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.