Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | FER | P16591 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | ROS1 | P08922 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 6/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9853425 | 0.75 | KDM4E (0.38) | KDM4EACVR1LRRK2PDGFRAFER | |
| SCHEMBL4913380 | 0.74 | KDM4E (0.41) | KDM4EACVR1LRRK2PDGFRAFER | |
| SCHEMBL1366624 | 0.72 | JUN (0.42) | KDM4EACVR1LRRK2PDGFRAFER | |
| SCHEMBL7336729 | 0.68 | CYP1A2 (0.55) | KDM4EACVR1LRRK2PDGFRAFER | |
| SCHEMBL16061960 | 0.68 | JUN (0.54) | KDM4EACVR1LRRK2PDGFRAFER | |
| SCHEMBL380110 | 0.65 | ALOX5 (0.61) | KDM4EACVR1LRRK2PDGFRAFER | |
| SCHEMBL17975286 | 0.63 | CSNK1G1 (0.56) | KDM4EACVR1LRRK2CSNK1G1CYP1A2 | |
| SCHEMBL21117454 | 0.60 | MAPT (0.42) | KDM4EACVR1LRRK2PDGFRAFER | |
| SCHEMBL9853252 | 0.60 | MAPT (0.45) | KDM4EACVR1LRRK2PDGFRAFER | |
| SCHEMBL9270079 | 0.60 | CSNK1G1 (0.56) | KDM4EACVR1LRRK2CSNK1G1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417534-A1 | Pyrido[2,3-b][1,4]benzoxazepin (and thiazepin)-6(5H)-ones and thiones and their use in the prevention or treatment of AIDS | Boehringer Ingelheim Pharmaceuticals Inc. (US) | 1991-03-20 | — | — | EP | disclosed |