Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NQO1 | P15559 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11628534 | 0.83 | ALDH1A1 (0.53) | MAPTL3MBTL1KMT2AALDH1A1POLB | |
| SCHEMBL7054411 | 0.81 | TEAD4 (0.47) | MAPTTDP1KMT2AALDH1A1POLB | |
| SCHEMBL9853810 | 0.81 | PTGS1 (0.54) | MAPTL3MBTL1TDP1LTA4HKMT2A | |
| SCHEMBL4370948 | 0.78 | PTGS1 (0.52) | MAPTLTA4HKMT2AALDH1A1MEN1 | |
| SCHEMBL4370679 | 0.78 | PTGS1 (0.52) | MAPTLTA4HCA12CA1CA2 | |
| SCHEMBL4374807 | 0.78 | PTGS1 (0.50) | TSHRLTA4HALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL9853817 | 0.77 | TBXAS1 (0.46) | MAPTKMT2AMEN1SMN1; SMN2PTGS1 | |
| SCHEMBL31460934 | 0.76 | ALDH1A1 (0.66) | MAPTLMNAATML3MBTL1TDP1 | |
| Hydrochloric Acid SCHEMBL9853816 | 0.76 | PTGS1 (0.49) | TSHRLTA4HKMT2AALDH1A1MEN1 | |
| SCHEMBL1282569 | 0.75 | GAA (0.38) | ALDH1A1SMN1; SMN2CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4959377-A | Phenoxypyridinamine compounds which are use as a dermatological composition | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-09-25 | — | — | US | claimed |
| EP-0405487-A1 | Phenoxypyridinamines and related compounds, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-01-02 | — | — | EP | disclosed |
| US-4959377-A | Phenoxypyridinamine compounds which are use as a dermatological composition | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1990-09-25 | — | — | US | disclosed |