Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 3/20 | 0.35 |
| ▸ | APEX1 | P27695 | 1/20 | 0.35 |
| ▸ | TDO2 | P48775 | 1/20 | 0.35 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9389831 | 0.88 | KDM4E (0.40) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL9383419 | 0.79 | PGR (0.39) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL9384409 | 0.74 | CA12 (0.39) | ALDH1A1POLBKMT2AMAPTMEN1 | |
| SCHEMBL9385854 | 0.73 | ALDH1A1 (0.41) | ALDH1A1HPGDHSD17B10KMT2AMEN1 | |
| SCHEMBL15691695 | 0.73 | ALDH1A1 (0.46) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL17051237 | 0.73 | ALDH1A1 (0.46) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL9388117 | 0.73 | ALDH1A1 (0.40) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL7385232 | 0.71 | ALDH1A1 (0.50) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL13536684 | 0.70 | IDO1 (0.49) | ALDH1A1KDM4EPOLBHPGDHSD17B10 | |
| SCHEMBL15691733 | 0.70 | ALDH1A1 (0.44) | ALDH1A1KDM4EPOLBHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0458549-A1 | N-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-11-27 | — | — | EP | disclosed |