Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9856589 | 0.72 | CYP2D6 (0.44) | MEN1KMT2ASLC6A2SLC6A4CYP3A4 | |
| SCHEMBL13290817 | 0.69 | ALDH1A1 (0.43) | MEN1KMT2ACYP3A4ALDH1A1LMNA | |
| SCHEMBL7305249 | 0.69 | ALDH1A1 (0.42) | CYP3A4CYP2D6ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL9856804 | 0.68 | CYP2D6 (0.42) | SLC6A2SLC6A4CYP3A4CYP2D6SLC6A3 | |
| SCHEMBL9475352 | 0.68 | VDR (0.46) | CYP3A4CYP2D6ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL6762680 | 0.68 | VDR (0.46) | CYP3A4CYP2D6ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL11269067 | 0.68 | TRPA1 (0.46) | SLC6A2SLC6A4CYP3A4CYP2D6SLC6A3 | |
| SCHEMBL8622006 | 0.68 | GAA (0.40) | MEN1KMT2ACYP3A4ALDH1A1SMN1; SMN2 | |
| SCHEMBL25403099 | 0.67 | ALDH1A1 (0.45) | MEN1KMT2ACYP3A4CYP2D6ALDH1A1 | |
| SCHEMBL7259363 | 0.67 | CA2 (0.46) | CYP3A4ALDH1A1LMNASMN1; SMN2CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |
| EP-0318233-A2 | Improvements in or relating to serotonin and norepinephrine uptake inhibitors | ELI LILLY AND COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |