Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9857027 | 0.86 | HTR2A (0.49) | HTR2AHRH1OPRM1DRD3OPRK1 | |
| SCHEMBL9856741 | 0.83 | HTR2A (0.49) | HTR2AHRH1SIGMAR1TAAR1CHRM1 | |
| SCHEMBL9856860 | 0.81 | HTR2A (0.49) | HTR2AHRH1SIGMAR1TAAR1CHRM1 | |
| SCHEMBL9856702 | 0.81 | TAAR1 (0.49) | HTR2AHRH1TAAR1CHRM1CHRM2 | |
| SCHEMBL9856740 | 0.80 | HTR2A (0.47) | HTR2AHRH1OPRM1DRD3OPRK1 | |
| SCHEMBL9857014 | 0.80 | TAAR1 (0.54) | HTR2AHRH1TAAR1CHRM1SLC6A2 | |
| SCHEMBL9857080 | 0.79 | HTR2A (0.50) | HTR2AHRH1SIGMAR1TAAR1CHRM1 | |
| SCHEMBL9857074 | 0.78 | CYSLTR2 (0.47) | HTR2AHRH1CHRM1SLC6A4BCHE | |
| SCHEMBL9856945 | 0.78 | HTR2A (0.49) | HTR2AHRH1SIGMAR1KCNH2TAAR1 | |
| SCHEMBL9857075 | 0.77 | CALM1 (0.54) | HTR2AHRH1TAAR1SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |