Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.44 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.43 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.43 |
| ▸ | HTR1B | P28222 | 2/20 | 0.43 |
| ▸ | HTR1D | P28221 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | NSD2 | O96028 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9857018 | 0.90 | SLC6A4 (0.46) | SLC6A4CYSLTR2CYSLTR1HTR2AHRH1 | |
| SCHEMBL9857201 | 0.90 | SLC6A4 (0.40) | SLC6A4CYSLTR2CYSLTR1HTR1BHTR1D | |
| SCHEMBL9856490 | 0.85 | CHRM2 (0.56) | SLC6A4ALDH1A1CYP2D6 | |
| SCHEMBL9856913 | 0.81 | HTR2A (0.46) | SLC6A4HTR1BHTR2AHRH1L3MBTL1 | |
| SCHEMBL9857036 | 0.80 | HTR2A (0.49) | SLC6A4HTR2AHRH1ALDH1A1KMT2A | |
| SCHEMBL8384207 | 0.78 | HTR2A (0.60) | SLC6A4HTR2AHRH1ALDH1A1L3MBTL1 | |
| SCHEMBL9856887 | 0.78 | HTR2A (0.49) | SLC6A4HTR2AHRH1KMT2AHRH3 | |
| SCHEMBL9857077 | 0.78 | HTR2A (0.49) | SLC6A4HTR2AHRH1KMT2AHRH3 | |
| SCHEMBL9856758 | 0.77 | HTR2A (0.45) | SLC6A4HTR2AHRH1KMT2AHRH3 | |
| SCHEMBL9856737 | 0.77 | SLC6A4 (0.54) | SLC6A4HTR2AHRH1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4996235-A | Selectively inhibiting the uptake of serotonin and norepinephrine | ELI LILLY AND COMPANY (US) | 1991-02-26 | — | — | US | disclosed |