SCHEMBL9856930

SCHEMBL9856930

COC(=O)c1cc(-c2nn(C)c(OC(F)F)c2Cl)c(F)cc1Cl

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.35
MAPT P10636 2/20 0.34
LMNA P02545 1/20 0.34
HPGD P15428 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
NTRK1 P04629 15/20 0.34
NPSR1 Q6W5P4 1/20 0.33
GUSB P08236 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9856872 0.91 MAPT (0.36) GAAMAPTHPGDSMN1; SMN2NTRK1
SCHEMBL9857115 0.90 LMNA (0.35) GAAMAPTLMNAHPGDSMN1; SMN2
SCHEMBL6433878 0.89 SMN1; SMN2 (0.33) GAAMAPTLMNAHPGDSMN1; SMN2
SCHEMBL7974134 0.89 NTRK1 (0.33) NTRK1
SCHEMBL4067916 0.89 NTRK1 (0.35) NTRK1
SCHEMBL9856794 0.89 BAZ2B (0.40) GAAMAPTLMNAHPGDSMN1; SMN2
SCHEMBL7960698 0.89 NTRK1 (0.36) NTRK1
SCHEMBL9738493 0.84 GAA (0.39) GAAMAPTLMNAHPGDSMN1; SMN2
SCHEMBL7961049 0.84 NTRK1 (0.31) NTRK1
SCHEMBL7994105 0.84 NTRK1 (0.32) NTRK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0443059-A1 3-(Substituted phenyl)pyrazole derivatives, salts thereof, herbicides therefrom, and process for producing said derivatives or salts NIHON NOHYAKU CO., LTD. (JP) 1991-08-28 EP claimed
US-5032165-A 3-(substituted phenyl)pyrazole derivatives, salts thereof, and herbicides therefrom NIHON NOHYAKU COMPANY, LTD. (JP) 1991-07-16 US claimed
EP-0361114-A1 3-(Substituted phenyl) pyrazole derivatives, salts thereof, herbicides therefrom, and process for producing said derivatives or salts NIHON NOHYAKU CO., LTD. (JP) 1990-04-04 EP claimed
JP-3163063-A None JP disclosed
US-5032165-A 3-(substituted phenyl)pyrazole derivatives, salts thereof, and herbicides therefrom NIHON NOHYAKU COMPANY, LTD. (JP) 1991-07-16 US disclosed
JP-H03163063-A 3-SUBSTITUTED PHENYLPYRAZOLE DERIVATIVE OR SALTS THEREOF, PRODUCTION THEREOF AND HERBICIDE NIPPON NOHYAKU CO LTD 1991-07-15 JP disclosed