SCHEMBL6433878

SCHEMBL6433878

CC(C)OC(=O)c1cc(-c2nn(C)c(OC(F)F)c2Cl)c(F)cc1Cl

nearest known ligand 0.42

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.33
LMNA P02545 2/20 0.33
MAPT P10636 2/20 0.33
HPGD P15428 1/20 0.33
NTRK1 P04629 12/20 0.32
TP53 P04637 1/20 0.32
ALDH1A1 P00352 1/20 0.31
POLB P06746 1/20 0.31
RXFP1 Q9HBX9 1/20 0.31
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9857115 0.90 LMNA (0.35) SMN1; SMN2LMNAMAPTHPGDNTRK1
SCHEMBL9856930 0.89 GAA (0.35) SMN1; SMN2LMNAMAPTHPGDNTRK1
SCHEMBL9856747 0.88 PPOX (0.35) SMN1; SMN2LMNAMAPTHPGDNTRK1
SCHEMBL4067916 0.87 NTRK1 (0.35) NTRK1
SCHEMBL7974134 0.87 NTRK1 (0.33) NTRK1
SCHEMBL9856794 0.87 BAZ2B (0.40) SMN1; SMN2LMNAMAPTHPGDGAA
SCHEMBL27320851 0.83 MAPT (0.34) SMN1; SMN2LMNAMAPTHPGDNTRK1
SCHEMBL9738493 0.82 GAA (0.39) SMN1; SMN2LMNAMAPTHPGDNTRK1
SCHEMBL7960698 0.82 NTRK1 (0.36) NTRK1
SCHEMBL9857255 0.82 MAPT (0.31) SMN1; SMN2LMNAMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1346638-B1 Herbicidal compositions BAYER CROPSCIENCE SA (FR) 2005-12-28 EP disclosed
US-6660692-B1 Herbicidal compositions comprising picolinafen AVENTIS CROPSCIENCE S.A. (FR) 2003-12-09 US disclosed
EP-1189510-B1 NEW HERBICIDAL COMPOSITIONS BAYER CROPSCIENCE SA (FR) 2003-10-01 EP disclosed
EP-1346638-A1 Herbicidal compositions Bayer CropScience S.A. (FR) 2003-09-24 EP disclosed