Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | PRKDC | P78527 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL583659 | 0.85 | HPGD (0.55) | LMNAHPGDPKMPRKDCALDH1A1 | |
| SCHEMBL29624374 | 0.85 | HPGD (0.55) | LMNAHPGDPKMPRKDCALDH1A1 | |
| Ethylene SCHEMBL6616812 | 0.82 | LMNA (0.44) | LMNAHPGDPKMPRKDCALDH1A1 | |
| SCHEMBL2799632 | 0.75 | PRKDC (0.42) | LMNAHPGDPKMPRKDCALDH1A1 | |
| SCHEMBL30286495 | 0.75 | PRKDC (0.42) | LMNAHPGDPKMPRKDCALDH1A1 | |
| SCHEMBL2174504 | 0.74 | PRKDC (0.79) | LMNAHPGDPRKDCALDH1A1MAPT | |
| Piperonal SCHEMBL9424697 | 0.74 | ALDH1A1 (0.72) | LMNAHPGDALDH1A1MAPTMEN1 | |
| SCHEMBL14070022 | 0.72 | LMNA (0.64) | LMNAHPGDALDH1A1MAPTMEN1 | |
| SCHEMBL15152345 | 0.72 | PRKDC (0.40) | LMNAHPGDPKMPRKDCALDH1A1 | |
| SCHEMBL15152237 | 0.72 | SMN1; SMN2 (0.51) | LMNAHPGDPKMPRKDCALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5070103-A | ANTILIPEMIC AGENTS, ARTERIOSCLEROSIS | TANABE SEIYAKU CO., LTD. (JP) | 1991-12-03 | — | — | US | disclosed |
| EP-0188248-B1 | NAPHTHALENE DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | TANABE SEIYAKU CO., LTD. (JP) | 1990-07-11 | — | — | EP | disclosed |
| US-4897418-A | ANTILIPEMIC AGENTS | TANABE SEIYAKU CO., LTD. (JP) | 1990-01-30 | — | — | US | disclosed |
| US-4771072-A | HYPOLIPIDEMIC ACTIVITY | TANABE SEIYAKU CO., LTD. (JP) | 1988-09-13 | — | — | US | disclosed |
| EP-0188248-A2 | Naphthalene derivatives, process for the preparation thereof and pharmaceutical composition containing same | TANABE SEIYAKU CO., LTD. (JP) | 1986-07-23 | — | — | EP | disclosed |