Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.68 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.68 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 4/20 | 0.36 |
| ▸ | RXRB | P28702 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9861167 | 0.84 | ALOX5 (0.56) | PTGS2PTGS1ALOX5HDAC3HDAC6 | |
| Tebufelone SCHEMBL43674 | 0.81 | PTGS2 (1.00) | PTGS2PTGS1ALOX5MEN1KMT2A | |
| SCHEMBL7696046 | 0.77 | PTGS2 (0.91) | PTGS2PTGS1ALOX5CYP1A2CYP2D6 | |
| SCHEMBL9860870 | 0.77 | PTGS2 (0.84) | PTGS2PTGS1ALOX5CYP1A2CYP3A4 | |
| SCHEMBL9420125 | 0.76 | PTGS2 (0.89) | PTGS2PTGS1ALOX5CYP1A2CYP2D6 | |
| SCHEMBL7704620 | 0.76 | PTGS2 (0.89) | PTGS2PTGS1ALOX5CYP1A2CYP2D6 | |
| SCHEMBL8153195 | 0.75 | HSD17B3 (0.47) | PTGS2PTGS1ALOX5HDAC3HDAC6 | |
| SCHEMBL9860963 | 0.75 | PTGS2 (0.85) | PTGS2PTGS1ALOX5CYP1A2CYP3A4 | |
| SCHEMBL9860705 | 0.74 | ALOX5 (0.56) | PTGS2PTGS1ALOX5ACHECYP1A2 | |
| SCHEMBL13278315 | 0.74 | SMN1; SMN2 (0.46) | PTGS2PTGS1ALOX5HDAC3HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0251408-B1 | NOVEL ANTI-INFLAMMATORY AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR REDUCING INFLAMMATION | THE PROCTER & GAMBLE COMPANY (US) | 1991-04-17 | — | — | EP | claimed |
| US-4708966-A | SUBSTITUTED DI-TERT-BUTYL PHENOL DERIVATIVES | THE PROCTER & GAMBLE COMPANY (US) | 1987-11-24 | — | — | US | claimed |
| EP-0251408-B1 | NOVEL ANTI-INFLAMMATORY AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR REDUCING INFLAMMATION | THE PROCTER & GAMBLE COMPANY (US) | 1991-04-17 | — | — | EP | disclosed |
| US-4708966-A | SUBSTITUTED DI-TERT-BUTYL PHENOL DERIVATIVES | THE PROCTER & GAMBLE COMPANY (US) | 1987-11-24 | — | — | US | disclosed |