Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 10/20 | 0.84 |
| ▸ | PTGS1 | P23219 | 9/20 | 0.84 |
| ▸ | ALOX5 | P09917 | 6/20 | 0.84 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tebufelone SCHEMBL43674 | 0.92 | PTGS2 (1.00) | PTGS2PTGS1ALOX5MEN1KMT2A | |
| SCHEMBL9861093 | 0.88 | ALOX5 (0.65) | PTGS2PTGS1ALOX5MEN1KMT2A | |
| SCHEMBL7696046 | 0.87 | PTGS2 (0.91) | PTGS2PTGS1ALOX5MEN1KMT2A | |
| SCHEMBL9178091 | 0.87 | PTGS2 (0.61) | PTGS2PTGS1ALOX5MEN1KMT2A | |
| SCHEMBL9420125 | 0.86 | PTGS2 (0.89) | PTGS2PTGS1ALOX5MEN1KMT2A | |
| SCHEMBL7704620 | 0.86 | PTGS2 (0.89) | PTGS2PTGS1ALOX5MEN1KMT2A | |
| SCHEMBL9178540 | 0.86 | PTGS2 (0.60) | PTGS2PTGS1ALOX5MEN1KMT2A | |
| SCHEMBL9860963 | 0.84 | PTGS2 (0.85) | PTGS2PTGS1ALOX5MEN1KMT2A | |
| SCHEMBL7701417 | 0.83 | ALOX5 (0.83) | PTGS2PTGS1ALOX5MEN1KMT2A | |
| SCHEMBL10551397 | 0.82 | PTGS2 (0.76) | PTGS2PTGS1ALOX5MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2000122-A | — | — | None | — | — | JP | disclosed |
| EP-0251408-B1 | NOVEL ANTI-INFLAMMATORY AGENTS, PHARMACEUTICAL COMPOSITIONS AND METHODS FOR REDUCING INFLAMMATION | THE PROCTER & GAMBLE COMPANY (US) | 1991-04-17 | — | — | EP | disclosed |
| US-4982006-A | Process for the preparation of certain substituted aromatic compounds | NORWICH EATON PHARMACEUTICALS, INC. (US) | 1991-01-01 | — | — | US | disclosed |
| JP-H02122-A | TERTIARY-BUTYLPHENYL COMPOUND USEFUL AS ANTIINFLAMMATORY AGENT | PROCTER & GAMBLE CO:THE | 1990-01-05 | — | — | JP | disclosed |
| US-4847303-A | UNSATURATED KETONES | THE PROCTER & GAMBLE COMPANY (US) | 1989-07-11 | — | — | US | disclosed |
| EP-0321432-A1 | Process for the preparation of certain substituted aromatic compounds | Norwich Eaton Pharmaceuticals, Inc. (US) | 1989-06-21 | — | — | EP | disclosed |
| EP-0318090-A2 | Tert-butyl phenyl compounds as anti-inflammatory agents | THE PROCTER & GAMBLE COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |
| EP-0251408-A1 | Novel anti-inflammatory agents, pharmaceutical compositions and methods for reducing inflammation | THE PROCTER & GAMBLE COMPANY (US) | 1988-01-07 | — | — | EP | disclosed |