Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11099488 | 0.86 | LMNA (0.40) | LMNAMEN1KMT2AHPGDTSHR | |
| SCHEMBL11594746 | 0.81 | HTT (0.47) | MEN1KMT2AHPGDALDH1A1KDM4E | |
| SCHEMBL32668832 | 0.80 | PKM (0.47) | LMNAMEN1KMT2AHPGDTSHR | |
| SCHEMBL14445127 | 0.80 | PKM (0.47) | LMNAMEN1KMT2AHPGDTSHR | |
| Hydrochloric Acid SCHEMBL11671567 | 0.80 | APP (0.47) | LMNAMEN1KMT2AHPGDTSHR | |
| Hydrochloric Acid SCHEMBL31199080 | 0.79 | PKM (0.46) | LMNAMEN1KMT2AHPGDTSHR | |
| Bromide SCHEMBL29484430 | 0.75 | LMNA (0.42) | LMNAMEN1KMT2ATSHREGFR | |
| SCHEMBL9863679 | 0.74 | LMNA (0.45) | LMNAMEN1KMT2AHPGDTSHR | |
| SCHEMBL9574173 | 0.74 | MAOB (0.43) | LMNAMEN1KMT2AEGFR | |
| SCHEMBL10076826 | 0.74 | MAOB (0.43) | LMNAMEN1KMT2AEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5011993-A | Method for the preparation of α1 [[(1,1-dimethylethyl)amino]methyl]-4-hydroxy-1,3-benzenedimethanol | SCHERING CORPORATION (US) | 1991-04-30 | — | — | US | disclosed |
| US-4952729-A | Intermediates in the preparation of alpha1(((1,1-dimethylethyl) amino) methyl)-4-hydroxy-1,3-benzenedimethanol | SCHERING-PLOUGH CORP. (US) | 1990-08-28 | — | — | US | disclosed |
| EP-0259159-A2 | Method for the preparation of alpha1- [[(1,1-Dimethylethyl) amino] methyl]-4-hydroxy-1,3-benzenedimethanol, and intermediates used in its preparation | SCHERING CORPORATION (US) | 1988-03-09 | — | — | EP | disclosed |