Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.45 |
| ▸ | CASP3 | P42574 | 2/20 | 0.45 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.45 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | WNT3A | P56704 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867484 | 0.84 | MAPT (0.47) | LMNAKDM4EHPGDCASP3SENP7 | |
| SCHEMBL9866780 | 0.79 | ALOX5 (0.55) | USP2LMNAKDM4EHPGDCASP3 | |
| SCHEMBL9867900 | 0.79 | HPGD (0.44) | USP2LMNAKDM4EHPGDCASP3 | |
| SCHEMBL9866757 | 0.78 | CYP2C9 (0.42) | LMNAKDM4EHPGDCASP3SENP7 | |
| SCHEMBL9867830 | 0.78 | ALOX5 (0.43) | USP2LMNAKDM4EHPGDCASP3 | |
| SCHEMBL9866482 | 0.78 | LMNA (0.50) | USP2LMNAKDM4EHPGDALDH1A1 | |
| SCHEMBL11630076 | 0.70 | CNR2 (0.55) | LMNAKDM4EHPGDCASP3SENP7 | |
| SCHEMBL5989988 | 0.70 | LMNA (0.48) | LMNAHPGDCASP3SENP7SENP6 | |
| SCHEMBL10174797 | 0.69 | CTNNB1 (0.66) | LMNAKDM4EHPGDALDH1A1MAPT | |
| SCHEMBL10661339 | 0.68 | CYP2C9 (0.58) | LMNAHPGDCASP3SENP7SENP6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006549-A | Antiinflammatory agents | MERCK & CO., INC. (US) | 1991-04-09 | — | — | US | claimed |
| EP-0399773-A1 | Novel 7-aroyl-4-hydroxy-3-methyl benzolfurans as dual inhibitors of cyclooxygenase and 5-lipoxygenase | MERCK & CO. INC. (US) | 1990-11-28 | — | — | EP | claimed |
| JP-3056473-A | — | — | None | — | — | JP | disclosed |
| US-5006549-A | Antiinflammatory agents | MERCK & CO., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| JP-H0356473-A | NOVEL 7-AROYL-4-HYDROXY-3-METHYL-BENZOFURAN AS DUAL INHIBITOR OF CYCLOOXYGENASE AND 5-LIPOXYGENASE | MERCK & CO INC | 1991-03-12 | — | — | JP | disclosed |
| EP-0399773-A1 | Novel 7-aroyl-4-hydroxy-3-methyl benzolfurans as dual inhibitors of cyclooxygenase and 5-lipoxygenase | MERCK & CO. INC. (US) | 1990-11-28 | — | — | EP | disclosed |