Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | CASP3 | P42574 | 2/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.44 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9867089 | 0.82 | MAPK1 (0.41) | ALOX5PTGS1PTGS2HPGDALDH1A1 | |
| SCHEMBL9867900 | 0.81 | HPGD (0.44) | ALOX5PTGS1PTGS2HPGDCASP3 | |
| SCHEMBL9867830 | 0.80 | ALOX5 (0.43) | ALOX5PTGS1PTGS2HPGDCASP3 | |
| SCHEMBL9864126 | 0.79 | USP2 (0.47) | ALOX5PTGS1PTGS2HPGDCASP3 | |
| SCHEMBL9869017 | 0.79 | ALOX5 (0.52) | ALOX5PTGS1PTGS2HPGDCASP3 | |
| SCHEMBL9867836 | 0.78 | SIRT1 (0.46) | PTGS2HPGDALDH1A1MAPTALOX15 | |
| SCHEMBL9866663 | 0.77 | ALOX5 (0.47) | ALOX5PTGS1PTGS2HPGDALDH1A1 | |
| SCHEMBL9868331 | 0.75 | CYP2C9 (0.44) | PTGS1PTGS2ALDH1A1MAPTALOX15 | |
| SCHEMBL9867484 | 0.74 | MAPT (0.47) | HPGDCASP3SENP7SENP6ALDH1A1 | |
| Prifelone SCHEMBL42678 | 0.72 | PTGS1 (1.00) | ALOX5PTGS1PTGS2HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006549-A | Antiinflammatory agents | MERCK & CO., INC. (US) | 1991-04-09 | — | — | US | claimed |
| US-5006549-A | Antiinflammatory agents | MERCK & CO., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| EP-0399773-A1 | Novel 7-aroyl-4-hydroxy-3-methyl benzolfurans as dual inhibitors of cyclooxygenase and 5-lipoxygenase | MERCK & CO. INC. (US) | 1990-11-28 | — | — | EP | disclosed |