Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.44 |
| ▸ | WNT3A | P56704 | 1/20 | 0.44 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866757 | 0.84 | CYP2C9 (0.42) | MAPTKMT2AHPGDMEN1NPC1 | |
| SCHEMBL9864126 | 0.84 | USP2 (0.47) | MAPTKMT2AHPGDMEN1NPC1 | |
| SCHEMBL9866645 | 0.78 | EDNRA (0.50) | MAPTKMT2AHPGDMEN1NPC1 | |
| SCHEMBL9867629 | 0.78 | ALDH1A1 (0.44) | MAPTKMT2AHPGDMEN1NPC1 | |
| SCHEMBL10439771 | 0.76 | MAPT (0.47) | MAPTKMT2AHPGDMEN1NPC1 | |
| SCHEMBL9866780 | 0.74 | ALOX5 (0.55) | MAPTKMT2AHPGDMEN1NPC1 | |
| SCHEMBL9867900 | 0.74 | HPGD (0.44) | MAPTKMT2AHPGDMEN1NPC1 | |
| SCHEMBL30785082 | 0.73 | L3MBTL1 (0.53) | MAPTKMT2AHPGDMEN1NPC1 | |
| SCHEMBL9867830 | 0.73 | ALOX5 (0.43) | MAPTKMT2AHPGDMEN1NPC1 | |
| SCHEMBL12475645 | 0.72 | MAPT (0.61) | MAPTKMT2AHPGDMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006549-A | Antiinflammatory agents | MERCK & CO., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| EP-0399773-A1 | Novel 7-aroyl-4-hydroxy-3-methyl benzolfurans as dual inhibitors of cyclooxygenase and 5-lipoxygenase | MERCK & CO. INC. (US) | 1990-11-28 | — | — | EP | disclosed |