Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.44 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9863936 | 0.92 | OPRM1 (0.43) | SLC6A2SLC6A4SLC6A3OPRM1OPRL1 | |
| SCHEMBL9864171 | 0.90 | SLC6A2 (0.46) | SLC6A2SLC6A4SLC6A3HPGDSMN1; SMN2 | |
| SCHEMBL9863865 | 0.86 | SLC6A3 (0.38) | SLC6A2SLC6A4SLC6A3OPRM1OPRL1 | |
| SCHEMBL9864499 | 0.85 | SLC6A4 (0.51) | SLC6A2SLC6A4SLC6A3ALDH1A1MAPT | |
| SCHEMBL9863726 | 0.83 | SLC6A3 (0.53) | SLC6A2SLC6A4SLC6A3OPRM1KCNH2 | |
| SCHEMBL9864222 | 0.82 | SLC6A4 (0.44) | SLC6A2SLC6A4SLC6A3OPRM1OPRL1 | |
| SCHEMBL9864627 | 0.78 | HDAC4 (0.38) | SLC6A4SLC6A3SMN1; SMN2OPRL1ALDH1A1 | |
| SCHEMBL9864254 | 0.78 | SLC6A4 (0.49) | SLC6A2SLC6A4SLC6A3HPGDALDH1A1 | |
| SCHEMBL9864011 | 0.77 | SLC6A4 (0.48) | SLC6A2SLC6A4SLC6A3L3MBTL1ALDH1A1 | |
| SCHEMBL9864630 | 0.76 | ALDH1A1 (0.34) | SLC6A2SLC6A4SLC6A3OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5047432-A | Antidepressants | THE BOOTS COMPANY PLC (GB) | 1991-09-10 | — | — | US | disclosed |
| US-4925879-A | ANTIDEPRESSANTS | BOOTS COMPANY, PLC (GB) | 1990-05-15 | — | — | US | disclosed |
| EP-0191542-B1 | ARYLCYCLOBUTYLALKYL AMINES AND THEIR USE AS ANTIDEPRESSIVE MEDICINES | The Boots Company PLC (GB) | 1988-06-08 | — | — | EP | disclosed |
| EP-0191542-A1 | Arylcyclobutylalkyl amines and their use as antidepressive medicines | The Boots Company PLC (GB) | 1986-08-20 | — | — | EP | disclosed |